Abstract
The feasibility of administering an oral dose of a 13 C-substrate and procuring metabolic or diagnostic information from its metabolism and conversion to 13 CO2 is attractive due to its noninvasive nature. The salient features of the 13 C -breath test are that they are noninvasive, non-radioactive, safe, simple, and effective. Breath tests have the potential to be useful screening methods that can be applied at the point of care (e.g., hospitals and physicians’ offices) and do not require patients to wait for hours or days for results. The noninvasive method is especially attractive for infants, children, pregnant and lactating women, seniors in poor health and subjects averse to the use of needles. The simplicity of the 13 C breath test makes it very applicable in a clinical setting: the physician can obtain valuable diagnostic information by distinguishing between two groups or populations on the basis of the recovery of 13CO2 from the ingested 13 C -substrate.
Published Version
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