Phase separation and physico-chemical variables of triton X-100 and cephradine monohydrate drug mixture: investigation of the impacts of nature of electrolytes and compositions

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Herein, the phase separation of triton X-100 (TNX-100) and cephradine monohydrate (CPM) drug (a first-generation cephalosporin family drug) mixture was studied in aqueous and in various aq. electrolytes (Na and K-based salts) media. As compared to the water environment, TNX 100 + CPM system demonstrated lower magnitudes of CP values in electrolytes solution. The outcomes exhibited dwindling CP values are: MCl < M2CO3 < M2SO4; (M = Na, K). Moreover, the (enthalpy change), (free energy change) and (entropy change), compensation temperature () and intrinsic enthalpy gain were also computed in the circumstances of TNX 100 + CPM mixture in water and aq. electrolytes media. The values of were obtained to be positive demonstrating the non-spontaneity of the process. The and values were positive in aq. medium and negative in aq. salts solutions where the magnitudes and values decreased with the growing contents of TNX 100/salts. The results suggest that the interaction forces between TNX 100 and CPM in a water environment are hydrophobic in nature with π–π interactions whereas in aq. salts media the recommended forces are hydrophobic and exothermic forces along with π–π interactions.