Abstract
In this paper, the interaction of imipramine hydrochloride (IMP, antidepressant drug) and a non-ionic surfactant Triton X-100 (TX-100) mixture in five different ratios through the tensiometric method in different solvents (aqueous/0.050 mol·kg−1 aqueous NaCl/0.250 mol·kg−1 aqueous urea (U)) were examined thoroughly at a temperature of 298 K. UV–Visible studies in an aqueous system of IMP + TX-100 mixtures were also investigated and discussed in detail. The pure (IMP and TX-100) along with the mixtures’ critical micelle concentration (cmc) were assessed by a tensiometric technique. The obtained deviation of the mixtures’ cmc values from their ideal values revealed the nonideal behavior of IMP + TX-100 mixtures amongst IMP and TX-100. Compared to aqueous systems, in the presence of aqueous NaCl, several changes in micelles/mixed micelles occurred, and hence a synergism/attractive interaction amongst components was found increased while in the existence of U, the synergism/attractive interaction between them decreased. The evaluated interaction parameter (βRb) value of mixed micelles showed the attractive or synergism between the IMP and TX-100. Various evaluated thermodynamic parameters in an aqueous system showed that the mixed micellization of the IMP + TX-100 mixture was an entropically spontaneous phenomenon, although the existence of salt in all studied systems can somewhat increase the spontaneity of the micellization process and in the aqueous U system, the spontaneity of the micellization process decreased. In an aqueous system, the interaction between IMP and TX-100 was also confirmed by UV–Visible study.
Highlights
Amphiphilic compounds undergo self-association into certain solvents to a rich diversity of phases liable upon their concentration as well as the solution environments, for instance, pH, temperature, and additive concentration, and so on [1,2,3,4,5]
Sanan and Mahajan [17] studied the interactions between mixed micelles of nonionic surfactant such as Tween and cationic surfactants such as dodecylbenzyldimethylammonium chloride and detected that the cmc of cationic surfactant decreased in the presence of Tween due to attractive interaction amongst employed components, as Tween monomers are intercalated into the cationic micelles
As an extension of our interest in drug and surfactant mixed system interactions [27,28,29,30], we investigated the interactions of Imipramine hydrochloride (IMP) drug through the non-ionic surfactant Triton X-100 (TX-100) in five different ratios mixtures using the tensiometric method in aqueous, 0.050 mol·kg−1 NaCl, and 0.250 urea (U) medium
Summary
Amphiphilic compounds undergo self-association into certain solvents to a rich diversity of phases liable upon their concentration as well as the solution environments, for instance, pH, temperature, and additive concentration, and so on [1,2,3,4,5]. As an extension of our interest in drug and surfactant mixed system interactions [27,28,29,30], we investigated the interactions of IMP drug through the non-ionic surfactant TX-100 in five different ratios mixtures using the tensiometric method in aqueous, 0.050 mol·kg−1 NaCl, and 0.250 urea (U) medium. Up until now, according to our information, the aggregation of the IMP drug in the presence of TX-100 of various mole fraction in non-aqueous system (salt, urea) has not been stated elsewhere This would possibly show as pharmaceutically significant in terms of unwanted side effects of the drug, which could be minimized if employed in the form of mixed micelles. Pure drug and surfactant stock solutions were prepared beyond their corresponding cmc value in an aqueous system or aqueous NaCl/aqueous urea solvent of the selected concentration.
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