Abstract
Bael (A. marmelos) is an important medicinal herb which has been and extensively used in Ayurveda, Siddha and other medicinal systems. The aim of this study is to evaluate the pharmacological activity of leaves part of the plant Aegle marmelos. Ethanolic extract of Aegle marmelos leaves prepared by successive extraction technique. This research carroed out to find out the Percentage Yield of Extract of Aegle marmelos, determination of LD50 of the EEAML as per OECD guidelines and to investigate the anti-depressant effect of Aegle marmelos leaves extract using tail suspension test (TST) and forced swim test (FST) parameters at dose levels of 200 mg/kg and 400 mg/kg respectively in albino swiss mice. Aegle marmelos leaves extract showed significant antidepressant activity probably due to GABA facilitatory action of phytoconstituents such as flavonoids, tannic acid, marmesinin, phenols, saponin etc. Results suggested that cortisol and corticosterone responded differently to severe stressors with cortisol being a quicker responder than corticosterone. Keywords: Aegle Marmelos, phytoconstituents, Anti-depressant activity
Published Version
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