Abstract
Recent progress in the field of aging has resulted in ever increasing numbers of compounds that extend lifespan in Caenorhabditis elegans. Lifespan extending compounds include metabolites and synthetic compounds, as well as natural products. For many of these compounds, mammalian pharmacology is known, and for some the actual targets have been experimentally identified. In this review, we explore the data available in C. elegans to provide an overview of which pharmacological classes have potential for identification of further compounds that extend lifespan.
Highlights
Pharmacological classes that extend lifespan of Caenorhabditis elegansEdited by: Alexey Moskalev, Institute of Biology Komi Scientific Centre Ural Division Russian Academy of Science, Russia
As a consequence of the seminal discoveries demonstrating that lifespan can be modulated by genes, it became clear that lifespan might be extended using chemicals (Johnson, 1990; Kenyon et al, 1993)
We explore the data available in C. elegans to provide an overview of which pharmacological classes have potential for identification of further compounds that extend lifespan
Summary
Edited by: Alexey Moskalev, Institute of Biology Komi Scientific Centre Ural Division Russian Academy of Science, Russia. Reviewed by: Hugo Aguilaniu, Centre National de la Recherche Scientifique - Ecole Normale Supérieure de Lyon, France Mark A. McCormick, Buck Institute for Research on Aging, USA. Recent progress in the field of aging has resulted in ever increasing numbers of compounds that extend lifespan in Caenorhabditis elegans. Lifespan extending compounds include metabolites and synthetic compounds, as well as natural products. For many of these compounds, mammalian pharmacology is known, and for some the actual targets have been experimentally identified. We explore the data available in C. elegans to provide an overview of which pharmacological classes have potential for identification of further compounds that extend lifespan
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