PH sensitive in-situ gel for ophthalmic delivery of ofloxacin and dexamethasone sodium phosphate: Formulation, development, and evaluation

Abstract

Ofloxacin and dexamethasone sodium phosphate will be used to create a gel-forming ocular medicine delivery system and examine its efficacy. Conventional dose forms have a number of drawbacks, including inadequate routes for drug transport to the posterior portion of ocular tissue, poor ocular drug bioavailability, and pulse-drug entry following topical administration and systemic exposure due to nasolacrimal duct outflow. Ofloxacin and Dexamethasone were obtained from Trimed Life Science Pvt. Ltd. Mumbai India. HPMC E50, Carbopol 930 was obtained from MET’s Institute of Pharmacy, Nashik. The developed formulation showed sustained drug release for 480 Minutes. While compared with marketed eye drop which shows drug release within 80 Minutes. The formulations were evaluated for different parameters like Clarity, pH of Sol, Gelling pH, Viscosity of Sol, Viscosity of gel, drug content, and Percentage Cumulative Drug Release. From these studies, formulation gives good clarity and satisfactory gelling pH along with good gelling capacity. The in situ gelling systems of Ofloxacin and Dexamethasone Sodium Phosphate were successfully developed. It also showed increased residence time with good gelling capacity at physiological pH and sustained drug release.