Abstract
Objective To evaluate the effects of PCPS on life-support of dogs with acute cardingenic shock (CS).Method Twenty healthy hybrid dogs were randomly(random number)divided into two groups.The acute CS canine model was established by ligature of the lAD coronary artery via open-chest surgery.The criteria of successful model were blood pressure dropped to 70%of the MAP or cardiac output dropped 30%.Dogs in the experimental group were treated with routine treatment including mechanical ventilation,intravenous injection of vasoucfive drugs such as dopamine,dobutamine and norepinephrine,and 5%bicarbonate as well as defibrillation along with PCPS.While dogs in control group were treated with routine treatment alone.Before modeling and at the beginning of modeling,15 rain,30 rain,60 rain and 90 rain after routine treatment,the hemodynamic variables including pH,PaO_2 and PaCO_2 were measured.The differences between two groups were compared using t-test and ANOVA.Results Eighteen(25 models were successfully made.(1)In the control group,MAP,CO deceased significantly(P＜0.05)and CVP increased significandy(P＜0.05)within 30 rain after modeling,PaO_2 decreased significantly(P＜0.05)and PaCO_2 increased significantly(P＜O.05)within 60 rain after modeling,and pH decreased significantly(P＜0.05)within 90 rain after modeling.(2)In the experimental group,MAP and PaO_2 increased significantly,and CVP decreased significantly(P＜0.05)within 15 rain after modeling,and PaCO_2 decreased significantly(P＜0.05)within 30 rain after modeling,and CO and pH remained unchanged.Compared with the control group,PaO_2 in experimental group was significantly higher(P＜0.05)and CVP was lower(P＜0.05)within 15 rain,MAP and CO were higher and PaCO_2 waa lower(P＜0.05)within 30 rain,and pH was higher(P＜0.05)within 60 min after modeling.Conclusions PCPS improves the hemodynamics and oxygen saturation in dogs with CS. Key words: Percutaneous cardio-pulmonary support; Cardiogenie shock; Animal model; Swaa-ganz vessel; Cardio-pulmonary bypass; Hemodynamics; Blood Gas analysis; Oxygen supply
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