Abstract
The rind of rambutan fruit (Nephelium lappaceum L.) has been reported to have a very strong antioxidant activity with IC50 value of 7.74 μg / mL. The fruit contains avonoids and phenolic . This compounds are potentially as hypolipidemic effect. This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats. This research method is the pre- and post-control group design. 25 rats were divided into 5 groups. Group I (negative control) were treated by a solution of 0.5% CMC-Na, group II (positive control) were treatedby cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg respectively. hiperkolesterlemia induction is done by giving a high cholesterol diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail egg yolk, water, PTU and feed high cholesterol consisting of margarine and standard feed. Treatment of mice was conducted for 2 weeks. The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%.Keywords: Antihypercholestrol, Nephelium Lappaceum L., High-cholesterol diet
Highlights
PENDAHULUAN Penyakit hiperkolesterol merupakan penyakit degeneratif yang banyak dijumpai kasusnya di Indonesia, dan menunjukkan kecenderungan peningkatan jumlah prevalensi setiap tahunnya
This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats
The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%
Summary
PENDAHULUAN Penyakit hiperkolesterol merupakan penyakit degeneratif yang banyak dijumpai kasusnya di Indonesia, dan menunjukkan kecenderungan peningkatan jumlah prevalensi setiap tahunnya. Salah satunya adalah hasil penelitian in vitro yang menerangkan bahwa ekstrak etanol dari kulit buah durian (Roongpisuthipong et al, 1991) dan kulit buah rambutan (Manaharan et al, 2012) memiliki aktivitas sebagai antihiperglikemik. Ekstrak etanol kulit buah rambutan mengandung epigallocatechin-3gallate (Palanisamy et al, 2011) yang memiliki aktivitas sebagai antihiperglikemia (WaltnerLaw et al, 2002) serta antioksidan kuat (Tabata et al, 2008).
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