Abstract
Probiotic of Lactobacillus casei Shirota strain is lactic acid bacteria that have benefits to enhance immunity system, as an antioxidant and has the ability to decrease the cholesterol level. The aim of this study was to determine the potential of Lactobacillus casei Shirota strain probiotic toward total cholesterol decreasing and SOD activity increasing in rats’ aorta with a high-cholesterol diet. This study used 25 male rats of Rattus novergicus Wistar strain that will be divided into 5 groups. The 1st group as the negative control, and the 2nd group as positive control. The positive control group was induced by high-cholesterol diet contained quail egg yolk, pure cholesterol, cholic acid and waste oil that were given for 3 weeks. The 3rd, 4th and 5th group were treated by probiotic Lactobacillus casei Shirota strain with variation dose of 3.6 x 107, 7.3 x 107 and 10.9 x 107 cells/kg bodyweight/day. The results showed that probiotic of Lactobacillus casei Shirota strain therapy dose of 10.9 x 107 cells/kg bodyweight/day can decrease the total blood cholesterol of rats’ serum that were given with high-cholesterol diet of about 32.0%. In addition, the probiotic of Lactobacillus casei Shirota strain therapy also increase the activity of SOD about 50.70%.
Highlights
Cardiovascular disease is caused by a disturbance in the heart and blood vessel function that are dangerous to health, the examples of cardiovascular diseases are coronary heart disease and stroke (Rastini, 2010)
The aim of this study is to determine the potential of Lactobacillus casei Shirota strain probiotic with therapeutic dose of 3.6 x 107, 7.3 x 107 and 10.9 x 107 cells/kg bodyweight/day of male white rats (Rattus norvegicus) that induced by high-cholesterol diet toward total cholesterol decreasing in rats’
Rats were divided into 5 groups: negative control, positive control that were given high-cholesterol diet for 3 weeks, and the three treatment groups were given high-cholesterol diet and treated with the probiotic of Lactobacillus casei Shirota strain orally with 3 dose (3.6 x 107, 7.3 x 107 and 10.9 x 107 cells/kg bodyweight/day) variations therapy
Summary
Cardiovascular disease is caused by a disturbance in the heart and blood vessel function that are dangerous to health, the examples of cardiovascular diseases are coronary heart disease and stroke (Rastini, 2010). The cause of these disease is atherosclerosis. High cholesterol diet that performed continuously will cause an accumulation of LDL cholesterol in the blood vessels and oxidation of LDL cholesterol (Towil & Pramono, 2014). It will produce of free radicals or ROS (Reactive Oxygen Species) in the body
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