Abstract
Plain Language SummaryMesangial proliferative GN (MesPGN) is one of the most frequent kidney diseases, and the pathogenesis of this disease is complex and involves several pathways. Blood coagulation is associated with MesPGN pathophysiology. Many coagulative mediators associated with these mechanisms have been evaluated and reported, individually. However, few studies have evaluated whole blood samples, especially in children, and the precise underlying mechanism(s) remains unclear. The total thrombus formation system (T-TAS®), new system, is a flow chamber system using a microchip for analyzing platelet thrombus formation (PTF), a coagulable state, under variable flow conditions, and can evaluate more closely living body. In this study, we assessed PTF in pediatric patients with MesPGN underflow condition using T-TAS. Twenty-nine pediatric patients definitively diagnosed with MesPGN by renal biopsy at Nara Medical University Hospital between 2015 and 2022 were evaluated. We assessed the PTF using T-TAS before, during, and after treatment, and compared with controls. The results showed that PTF of MesPGN patients was enhanced before treatment and was improved after the end of treatment.
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