Clinicopathological characteristics in 996 cases with renal biopsy

Abstract

Objectives To retrospectively analyze the pathologic type of renal biopsy and the change of disease spectrum of recent 10 years in our hospital. Methods The clinical data of 996 patients with renal biopsy from February 2006 to February 2016 in our department were collected and analyzed. Results Among the 996 patients, primary glomerular disease (PGD) was 76.31%, secondary glomerular disease (SGD) was 21.18%, renal tubulointerstitial was 2.21% and hereditary kidney disease was 0.30%. Among the PGD, IgA nephropathy was the most common pathological type with 238 cases (31.32%), followed by mesangial proliferative glomerulonephritis with 199 cases (26.18%), membranous nephropathy with 127 cases (16.71%). Among the SGD, lupus nephritis was the most common pathological type with 76 cases (36.02%), followed by henoch-schonlein purpura nephritis with 56 cases (26.54%) and hepatitis B virus associated glomerulonephritis (HBV-GN) with 24 cases (11.37%). Among the PGD, nephritic syndrome was the most common clinical manifestation with 446 cases (58.68%), followed by chronic glomerulonephritis with 223 cases (29.34%) and latent glomerulomephritis with 69 cases (9.08%). Conclusions PGD is the most frequent glomerular disease in clinic. IgA nephropathy is the most common pathological type in PGD and the proportion of membranous nephropathy increases significantly in recent years. In SGD, Lupus nephritis is the most common pathological type and the proportion of HBV-GN also increases significantly. Key words: Kidney Diseases; Biopsy, Needle