Clinical and pathological analysis of elderly patients after renal biopsy in Guangxi

Abstract

Objective To analyze the common clinical and pathological types of elderly patients after renal biopsy in Guangxi. Methods By means of enrolling 373 elderly patients (aged ≥ 60 years) who had undergone renal biopsy in the First Affiliated Hospital of Guangxi Medical University from August 2012 to August 2015, and collecting the data of gender, age, nationality, clinical diagnosis, kidney pathological diagnosis, etc, the renal disease spectrum of elderly patients were retrospectively analyzed with the SPSS13.0 software. And statistical descriptions were made for the categorical variables with frequency and percentage. Results The most common clinical syndrome in elderly patients after renal biopsy was nephrotic syndrome (NS, 50.1%), followed by acute kidney injury (AKI, 28.7%) and chronic nephritis syndrome (15.5%). In the elderly patients after renal biopsy, primary glomerular diseases accounted for 67.8%, and secondary glomerular diseases accounted for 26.8%. In primary glomerular diseases, idiopathic membranous nephropathy (IMN, 71.9%) was the leading renal histopathological type, followed by minimal change disease (MCD, 9.9%) and focal segmental glomerulosclerosis (FSGS, 7.9%). In the secondary glomerular diseases, the most common type was ANCA-associated vasculitis (AAV, 31.0%), followed by lupus nephritis (20.0%) and diabetic nephropathy (12%). In the NS of elderly patients, the most common cause was IMN (75.4%), followed by MCD (5.3%) and FSGS (5.3%). In the AKI of elderly patients after renal biopsy, the most common pathological type was IMN (26.2%), followed by AAV (24.3%). Conclusion NS was the most common clinical syndrome of elderly patients after renal biopsy in Guangxi. IMN was the most common pathological type in the elderly NS and primary glomerular diseases; AAV was the most common cause of secondary glomerular diseases; and IMN and AAV were the main causes of AKI. Key words: Elderly; Renal pathology; Nephrotic syndrome; Idiopathic membranous nephropathy; Acute kidney injury; ANCA-associated vasculitis