Lipophagy and mitophagy in renal pathophysiology.

Abstract

The lysosomal autophagic pathway plays a fundamental role in cellular and tissue homeostasis, its deregulation is linked to human pathologies including kidney diseases. Autophagy can randomly degrade cytoplasmic components in a non-selective manner commonly referred to as bulk autophagy. In contrast, selective forms of autophagy specifically target cytoplasmic structures such as organelles and protein aggregates thereby being important for cellular quality control and organelle homeostasis. Research during the past decades has begun to elucidate the role of selective autophagy in kidney physiology and kidney diseases. In this review, we will summarize the knowledge on lipophagy and mitophagy, two forms of selective autophagy important in renal epithelium homeostasis and discuss how their deregulations contribute to renal disease progression.