Abstract
Abstract This reaction is an acid‐promoted synthesis of coumarin derivatives from the condensation of phenols and β‐ketoesters or β‐keto carboxylic acids and is generally known as the Pechmann reaction. This reaction, under acidic conditions, involves an esterification or transesterification, followed by a cyclization and dehydration. It has been found that the outcome of this reaction depends on the nature of phenols, β‐keto esters, and condensation reagents. The study finds that only phenols with electron‐donating groups at the meta ‐position of the hydroxy group readily undergo the Pechman condensation. On the other hand, the α‐substituents and γ‐substituents on β‐keto esters retard this reaction. This reaction has general application in the preparation of coumarin derivatives.
Published Version
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