PD48-10 MULTIPLE TRANSVERSE INCISIONS PATCHED WITH TACHOSIL® IN PEYRONIE’S DISEASE: PRELIMINARY DATA OF AN ONGOING, PROSPECTIVE, NON-RANDOMIZED STUDY

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Peyronie's Disease (PD48)1 Sep 2021PD48-10 MULTIPLE TRANSVERSE INCISIONS PATCHED WITH TACHOSIL® IN PEYRONIE’S DISEASE: PRELIMINARY DATA OF AN ONGOING, PROSPECTIVE, NON-RANDOMIZED STUDY Afonso Castro, Miguel Fernandes, Miguel Miranda, Pedro Simões Oliveira, Natalia Martins, José Palma dos Reis, and Francisco E. Martins Afonso CastroAfonso Castro More articles by this author , Miguel FernandesMiguel Fernandes More articles by this author , Miguel MirandaMiguel Miranda More articles by this author , Pedro Simões OliveiraPedro Simões Oliveira More articles by this author , Natalia MartinsNatalia Martins More articles by this author , José Palma dos ReisJosé Palma dos Reis More articles by this author , and Francisco E. MartinsFrancisco E. Martins More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002070.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Peyronie’s disease (PD) can be both physically and psychologically distressing to the patient. Although invasive, surgery remains the most reliable and effective treatment option. However, complications are not negligible. We present our preliminary data of an ongoing, prospective, non-randomized study of potent patients with PD who underwent multiple transverse incisions (MTI) covered with Tachosil®. Severe dorsal/dorsolateral deformity and/or further penile shortening were the primary therapeutic endpoints. METHODS: Between January 2018 and February 2020, patients with dorsal/dorsolateral deformity and stable PD were included in this analysis. All patients underwent a penile duplex ultrasound study (PDUSS) and SHIM-5 (Sexual Health Inventory for Males) questionnaire to assess erectile function both objectively and subjectively before and after surgery. PGI-I (Patient Global Impression of Improvement) was used to assess patient satisfaction. RESULTS: 23 patients underwent MTI+Tachosil® (median 4 incisions; range 3-6) after ≥12 months of deformity duration and without evidence of progression. Median age was 66 years (range 49 - 76). Median preoperative compound curvature was 60 degrees (range 30-90), 19 (83%) had dorsal curvature, 3 patients (13%) had dorsolateral deformity and 1 had lateral curvature (4%). Total straightness was achieved in 20 patients (87%) and residual curvature was evidenced in 3 (13%). Erectile rigidity sufficient for penetrative intercourse was maintained in all patients at last follow-up, not displaying erectile dysfunction progression. There were no significant changes in PDUSS scores post-operatively. SHIM-5 scores improved from 13 (range 12-16) pre-operatively, to 19 (range 18-21) post-operatively. Median postoperative PGI-I scores were 2 (much better). No penile length reduction was observed. One patient experienced self-resolution of penile hematoma, 5 patients noted transient glandular hypoesthesia with only 1 developing prolonged sensation impairment. CONCLUSIONS: MTI with Tachosil grafting is feasible, well tolerated, easy and quick to perform surgical technique for the treatment of PD. It avoids creation of large tunical defects with subsequent veno-occlusive dysfunction, and provides additional hemostasis, while preserving erectile function. Most complications were minor and transient (Clavien-Dindo I or II). Source of Funding: The authors received no specific funding for this work © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e842-e842 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Afonso Castro More articles by this author Miguel Fernandes More articles by this author Miguel Miranda More articles by this author Pedro Simões Oliveira More articles by this author Natalia Martins More articles by this author José Palma dos Reis More articles by this author Francisco E. Martins More articles by this author Expand All Advertisement Loading ...