PD48-12 RELATIONSHIP OF FACTORS ASSOCIATED WITH PEYRONIE'S DISEASE (PD) THAT AFFECT PD BOTHER AND ERECTILE DYSFUNCTION

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Peyronie's Disease1 Apr 2015PD48-12 RELATIONSHIP OF FACTORS ASSOCIATED WITH PEYRONIE'S DISEASE (PD) THAT AFFECT PD BOTHER AND ERECTILE DYSFUNCTION Ege Serefoglu, Mehmet Berktas, Faysal Yafi, Ted Smith, Gregory Kaufman, Genzhou Liu, and Wayne Hellstrom Ege SerefogluEge Serefoglu More articles by this author , Mehmet BerktasMehmet Berktas More articles by this author , Faysal YafiFaysal Yafi More articles by this author , Ted SmithTed Smith More articles by this author , Gregory KaufmanGregory Kaufman More articles by this author , Genzhou LiuGenzhou Liu More articles by this author , and Wayne HellstromWayne Hellstrom More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2769AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Despite the known association between Peyronie's disease (PD) and erectile dysfunction (ED), the underlying pathophysiologic mechanisms of ED in men with PD remain unknown. The aim of this analysis is to elucidate factors that have an impact on PD bother and erectile function in subjects with PD. METHODS Data from collagenase clostridium histolyticum (CCH) phase 3 studies (IMPRESS I and II), which included 832 men over 18 years old with PD symptoms >12 months and penile curvature deformityof 30°-90°, were analyzed post hoc. Scores from the International Index of Erectile Function erectile function domain (IIEF-EF) and the Peyronie's Disease Questionnaire (PDQ) were used in the analysis. A Covariance Analysis and Linear Structural Equations (CALIS) procedure to estimate relationships of selected variables on bother and ED associated with PD was performed. RESULTS The CALIS procedure using data of subjects (mean age 57.3±8.3 years and mean penile curvature deformity 49.8°±14.2°) revealed relationships between penile curvature deformity, perceived penile shortening, pain during intercourse, presence of plaques, PD bother, and erectile function. CONCLUSIONS The results of this analysis suggest that PD bother can come from several different sources: penile curvature deformity, perceived penile shortening, and especially pain during intercourse. Also, PD bother and pain during intercourse both appear to have a direct impact on erectile function. Additional prospective studies are warranted to further investigate these relationships. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e970 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ege Serefoglu More articles by this author Mehmet Berktas More articles by this author Faysal Yafi More articles by this author Ted Smith More articles by this author Gregory Kaufman More articles by this author Genzhou Liu More articles by this author Wayne Hellstrom More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...