Abstract
The two DNA polymerases (A and B) previously reported in rat brain show some different properties. Enzyme A sediments around 9 S on sucrose gradients, and enzyme B at around 3–4 S. In the cerebellum, DNA polymerase A is the more active in very young animals but peaks at around the 6th day after birth. DNA polymerase B is more active than enzyme A in the cerebella from older animals. In the cerebral cortex DNA polymerase A activity is higher than that of enzyme B in the fetal stage but the activity of polymerase A is much lower than that of polymerase B at all post-natal ages studied. Possible functions of enzymes A and B are discussed.
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