Abstract
Objective To investigate the pathogenic bacteria and drug resistance of peritoneal dialysis related peritonitis. Methods Retrospectively analysis of 86 patients From January 2014 to December 2017 with peritoneal dialysis(PD) related peritonitis of the dialysis center of the first affiliated hospital of USTC, included pathogenic bacteria, drug sensitivty test and prognosis was performed. Results Among all the patients, 58 cases cultured positive (67.4%). In culture positive bacteria, 43 gram-positive cocci (74.1%), 6 gram-negative cocci (10.3%) and 9 fungus (15.5%). Staphylococcus epidermidis was the most common gram-positive cocci (22.4%). Bacterium coli was the most common gram-negative bacilli (5.2%). Fungi was mostly found in smooth candida. Drug sensitivty test results indicated that gram-positive cocci had the highest resistance rates of 51.2% to penicillin G, all were sensitive to vancomycin. Gram-negative bacteria had similar resistance rate to aztreonam, ceftriaxone and ciprofloxacin while it had no resistance to amikacin. Among all the patients, 71 cases (82.6%) were cured, 13 cases (16.7%) removed peritoneal dialysis catheter and transferred to hemodialysis, 2 cases cultured positive, but they refused treatment. There were 45 cases peritonitis in the first year of PD, had the rate of 52.3%, that was significantly higher than other dialysis year. Conclusions Gram-positive cocci are still the main pathogens of PD related peritonitis in our dialysis center. The first year of PD is the easiest infection stage, patients should be strengthened education. In empirical treatment, we recommend vancomycin combined with aminoglycosides. Fungal peritonitis is the main causes for patients' dropout of PD. Key words: Peritoneal Dialysis; Peritonitis; Bacteria; Drug Tolerance
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call