Pathogen distribution characteristics and risk factors of pulmonary tuberculosis complicated with pulmonary infection people's hospital of mianzhu city, sichuan province

Abstract

Objective To explore the risk factors of pulmonary tuberculosis complicated with pulmonary infection and to analyze the pathogens characteristics. Methods 158 patients diagnosed with tuberculosis were chosen. patient medical records with clinicians report were collected, risk factors of pulmonary tuberculosis in patients with pulmonary infection were analyzed by statistical review of specialized personnel to fill in the unified form. With the characteristics of fresh sputum, pathogen isolation and identification of bacteria were analyzed. Results Secondary pulmonary tuberculosis, pulmonary tuberculosis retreatment, acid fast sputum smear staining was negative, long- term use of glucocorticoid, long- term use of broad- spectrum antibiotics, with basic diseases as the variables were associated with risk factors of pulmonary infection, there were statistically significant(P< 0.05). Etiological analysis showed that gram positive bacteria, gram negative bacteria, fungi accounted for pathogens,70.25%,3.86%,25.95%.Among them,Klebsiella pneumoniae, Pseudomonas aeruginosa and Streptococcus pneumoniae accounted for the highest proportion. Drug sensitive test showed cefepime(Ma Siping)the highest sensitivity(87.80%), compound sulfamethoxazole were the most resistance(72.00%). Conclusion Pulmonary tuberculosis complicated with pulmonary infection risk factors were: Pulmonary tuberculosis, pulmonary tuberculosis retreatment, acid fast sputum smear staining was negative, long- term use of glucocorticoid,long- term use of broad- spectrum antibiotics, with basic diseases. Patients of routine application of penicillin and cephalosporin effect of pulmonary tuberculosis complicated with pulmonary infection is not necessarily ideal. It should be given to drug use three generation cephalosporins, quinolones and aminoglycosides, such as high sensitivity in drug sensitivity results back to front. Key words: Pulmonary tuberculosis; Pulmonary infection; Pathogen