Abstract
Channel-facilitated transport of metabolites across biological membranes results in excess noise in the current carried by small ions. This noise originates from fluctuations of the number of metabolite molecules in the channel due to their diffusion. We have carried out a theoretical study of particle number fluctuations in a cylindrical pore. First, we obtain the power spectral density of these fluctuations as a function of pore length and radius, as well as the diffusion constants of the particle in the pore and in the bulk, in the absence of particle–pore interactions. We then perform three-dimensional Brownian dynamics simulations that show excellent agreement with the analytical result. Finally, we demonstrate that explicit expressions for the low-frequency limit of the spectral density can be found even when the particle interacts with the pore.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
