Abstract
Antigenic similarities and differences between 6 multiple sclerosis (MS) brains and T non-MS brains autopsy specimens have been elucidated by crossed Immunoelectrophoresis (CIE) using antibodies prepared by immunization of rabbits with cytoplasmic and microsomal fractions of the brains. The following data were obtained: l) a “measles” antigen and two specific antigens have been purified more than 3000 fold from MS brains by means of molecular filtration and DEAE cellulose chromatography. 2) all 3 antigens have a molecular weight between 105-106 daltons and isoelectric points between 3.5-6.0. 3) “measles” antigen has been also found in 3 out of 7 non-MS brains, however, it did not stimulate antibody formation in rabbits in contrast to measles antigen of MS brain. The significance of the above mentioned data is discussed in view of the immunological abnormalities previously found in MS patients. It cannot be excluded that the antigens found represent one or more viral antigens.
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