Abstract
The present study was devoted to an immunochemical elucidation of antigenic similarities and differences between cytoplasmic and microsomal fractions of six multiple sclerosis (MS) and seven non-MS brain autopsy specimens. The antigenic composition of the samples studied was traced by crossed Immunoelectrophoresis using antibodies made by immunization of rabbits with the corresponding fraction. The following data were obtained: (1) An antigen present in measles-infected Vero cells and two specific antigens have been purified more than 3000-fold from MS brains using molecular filtration and DEAE cellulose chromatography; (2) all three antigens have a molecular weight between 105 and 106 daltons and isoelectric points between 3.5 and 6.0; and (3) measles antigen has been also found in three out of seven non-MS brains; however, it did not stimulate antibody formation in rabbits, in contrast to measles antigen of MS brain.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
