Abstract
Intermittent administration of parathyroid hormone (PTH) stimulates bone formation, and continuous infusion of PTH stimulates bone resorption. The preclinical and clinical studies showed that PTH improved bone structure such as trabecular connectivity and cortical thickness, as well as increased bone mass. Its contribution to bone strength is produced by the different mechanism from the anti-resorptive agent. Assessment of bone geometry and site-specific bone change using CT will be required to evaluate its efficacy of anabolic agent on bone quality.
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