Abstract
Parathyroid hormone (PTH [1-34]) stimulates bone formation and activates bone remodeling, resulting in increase of bone mass and strength. The effect on bone quality appears through the different mechanism from the anti-resorptive agents. The anti-resorptive agent maintains the trabecular microstructure, decreases the cortical porosity and increases the degree of mineralization, meanwhile, the anabolic agent such as PTH increases trabecular number and cortical thickness, decreases the mineralization and increases cortical porosity. Both different mechanisms of anti-resorptive and anabolic agents improve the biomechanical properties of bone. Micro-CT and clinical CT images demonstrate the effect of PTH on bone quality.
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