Abstract
Parallels in the pathogenesis of SARS-CoV-2 and M. tuberculosis: asynergistic or antagonistic alliance?
Highlights
The world is facing a major challenge of the new pneumonia condition termed COVID-19 caused by SARSCoV-2, the seventh member of human coronaviruses
Based on the nonspecific nature of BCG and its capacity to elicit both innate and adaptive immunity, BCG vaccine has been suggested as a preventive measure against SARS-CoV-2 infection or to reduce COVID-19 severity, especially among children who have already been vaccinated with BCG [38,39]
Conclusion & future perspective SARS-CoV-2 and M. tuberculosis infections have some important parallels with regards to cell entry, immune response and immune evasion
Summary
The world is facing a major challenge of the new pneumonia condition termed COVID-19 caused by SARSCoV-2, the seventh member of human coronaviruses. Co-infection of SARS-CoV-2 and M. tuberculosis may exacerbate the pathologies that are associated with each pathogen. Severe infection of type II pneumocytes with SARS-CoV-2 can cause regeneration failure of the cells and lead to lesions in the lungs, accelerated bronchial damage and lung disease [17].
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