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Abstract
Abstract The synthesis of 1,2,4-trisubstituted imidazoles was demonstrated via the solid phase synthesis of N -alkyl- N -(β-keto)amides using a carbazate linker. The approach enabled the assembly of a diverse number of N -alkyl- N -(β-keto)amide intermediates in good yield and purity. Subsequent cyclisation in solution using NH 4 OAc led to the preparation of 1400 1,2,4-trisubstituted imidazoles.
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