Abstract
An efficient method for the preparation of 1-acyl-3,4-dihydroquinazoline-2(1H)-thiones 5 has been developed. The reaction of N-[2-(azidomethyl)phenyl] amides 3, easily prepared by a three-step sequence starting with (2-aminophenyl)methanols, with Ph3P, followed by CS2, allowed generation of N-[2-(isothiocyanatomethyl)phenyl]-amide intermediates 4, which underwent cyclization on treatment with NaH to furnish the corresponding desired products in generally good yields.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.