Abstract
Physical activity is any body movement that occurs due to skeletal muscle contractions that require energy expenditure. Overtraining can trigger oxidative stress due to chronic systemic hypoxia, cause an increase in systemic inflammatory response and multiorgan damage, and accelerate the aging process. The aging process is influenced by many factors, one of which is high-intensity swimming exercise which triggers the emergence of free radicals and leads to systemic oxidative stress. High-intensity swimming exercise is associated with an increase in Reactive Oxygen Species (ROS). The Papaya plant is famous for its therapeutic and nutritional properties. Papaya leaves contain secondary metabolites from papaya leaf extract including tannins, saponins, flavonoids, phenolics, and alkaloids. Papaya leaf extract has strong medicinal properties as an antibacterial, antiviral, antitumor, and antioxidant. This research is an experimental study with a post-test-only control group design. The sample in this study were male white rats (Rattus norvegicus) with an age range of 3-4 months with an average body weight range of 180-200 grams. As many as 36 rats were divided into 2 treatment groups. Treatment group 1 (P1) rats were given high-intensity swimming exercise treatment and aquabidest. Treatment group 2 (P2) rats were given high-intensity swimming exercise treatment and papaya leaf extract 60mg / 200g BB orally. Each treatment was carried out for 21 days. The data obtained will be analyzed using an independent sample T-test. The results of this study obtained: (1) the average MDA levels showed that the P1 group (1.02±0.064) was higher than the P2 group (0.86±0.44) with a value of p<0.001; (2) the average SOD level in the P2 group (2.72±0.437) was higher than P1 (1.46±0.288) with p<0.001; (3) the average number of Leydig cells in the P1 group (13.0±5.05) was lower than in the P2 group (30.0±5.05) with p<0.001. This study concluded that papaya leaf ethanol extract in rats was able to reduce MDA levels, increase SOD levels and increase the number of Leydig cells in male rats given high-intensity swimming exercise.
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