Abstract
AbstractAn alternative method related to the formation of 3‐(hetero)arylpropynamides using palladium/Cs2CO3, regiochemically‐controlled coupling of isocyanides with 1,1‐dibromo‐1‐alkenes is described. It was found that the presence of palladium is crucial in the media so activated the C−Br bond in the 1,1‐dibromo‐1‐alkenes. Subsequent isocyanide insertion followed by reductive elimination yielded an intermediate that could be easily converted to the desired product in satisfactory yields.magnified image
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