Abstract
AbstractWe report the addition reaction of lithium enol ethers to fluoroalkyl imines. A range of different fluoroalkyls and lithiated reagents are well tolerated. Diastereoselective addition of lithium vinyl ethers to fluoroalkyl N‐tert‐butylsulfinylimines is disclosed, providing enantiomerically enriched α‐fluorinated amines in up to 98% yield. This general approach led to the diastereoselective formation of various amino alcohols and amino ethers, which are difficult to obtain by other methods.
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