Abstract
Paliperidone-induced mania: a case report
Highlights
Paliperidone is an atypical antipsychotic derived from 9-hydroxyrisperidone
This report will discuss the case of a patient who was hospitalized with a diagnosis of schizophrenia and manic symptoms during paliperidone palmitate treatment
We reported on the case of a patient who had a diagnosis of schizophrenia and developed manic symptoms after being treated with paliperidone palmitate
Summary
Paliperidone is an atypical antipsychotic derived from 9-hydroxyrisperidone. Paliperidone shows antagonistic activity on dopamine D2, serotonin 5HT2A, and histamine H1 receptors as well as the alpha[1] and alpha[2] adrenergic receptors[1]. Paliperidone palmitate is an injectable form of paliperidone that has long-lasting potency and has been developed to improve treatment compliance in patients who have schizophrenia. Paliperidone shows high binding affinity to dopamine D2 and serotonin 5HT2A receptors. It shows significant binding affinity to α2a receptors. This leads to an increase in serotonin release, which may induce antidepressant activity[2]. It seems to be paradoxical, manias that are associated with atypical antipsychotic drugs have been reported in the literature[3]. This report will discuss the case of a patient who was hospitalized with a diagnosis of schizophrenia and manic symptoms during paliperidone palmitate treatment
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