Abstract
Chondrosarcoma, a primary malignant bone cancer, has potential for local invasion and distant metastasis, especially to the lungs. Patients diagnosed with it show poor prognosis. Paeonol (2'-hydroxy-4'-methoxyacetophenone), the main active compound of traditional Chinese remedy Paeonia lactiflora Pallas, exhibits anti-inflammatory and anti-tumor activity; whether paeonol regulates metastatic chondrosarcoma is largely unknown. Here, we find paeonol do not increase apoptosis. By contrast, at non-cytotoxic concentrations, paeonol suppresses migration and invasion of chondrosarcoma cells. We also demonstrate paeonol enhancing miR-141 expression and miR-141 inhibitor reversing paeonol-inhibited cell motility; paeonol also reduces protein kinase C (PKC)δ and c-Src kinase activity. Since paeonol inhibits migration and invasion of human chondrosarcoma via up-regulation of miR-141 via PKCδ and c-Src pathways, it thus might be a novel anti-metastasis agent for treatment of metastatic chondrosarcoma.
Highlights
Chondrosarcoma is derived from abnormal proliferation cartilage and accounts for about 26% of bone cancer
We examined whether paeonol induced apoptosis in human chondrosarcoma cells by triphosphate nick-end labeling (TUNEL) staining and caspase 3 activity assay
Unlike other mesenchymal malignancies, such as osteosarcoma and Ewing’s sarcoma, whose long-term survival dramatically increased with the advent of systemic chemotherapy, data indicate that chondrosarcoma shows a predilection for metastasis to lungs, meaning poor prognosis due to lack of effective adjuvant therapy [28,29]
Summary
Chondrosarcoma is derived from abnormal proliferation cartilage and accounts for about 26% of bone cancer. It usually occurs in males aged 10–80 years, most tumors appearing on the scapula, sternum, ribs, or pelvis [1,2]. Distant metastasis means poor prognosis and high incidence of fatality associated with this mesenchymal malignancy due to lack of an effective adjuvant therapy, making it important to explore novel remedies [5,6]. Tumor invasion and metastasis are prominent biological traits of cancer cells [7]. Mortality in such cases results from spread to distant organs.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call