P238: Mucosal vaccination prevents spontaneous colorectal carcinoma and induces long-term immunity in mice

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The goal of tumor vaccination is to induce a long-lived antigen-specific T cell response that can prevent the development of spontaneous cancers or induce regression of established tumors. Previous efforts targeting carcinoembryonic antigen (CEA) by recombinant poxvirus vectors have shown some promise in generating CEA-specific T cell responses but this has not yet resulted in significant clinical responses in patients with cancer. The lack of therapeutic activity may be associated with anti-vector neutralizing antibody titers, the weak antigenicity of CEA and the lack of priming in an appropriate microenvironment.