P-119 - Ex-vivo vasorelaxation induced by polyphenol-rich extracts from plant, fruits and berries on porcine coronary artery rings

Abstract

The aim of the present study was to investigate if the polyphenol content of various commercial plant, fruits and berries extracts was linked to vasorelaxation properties. A total of 24 commercial extracts (including black currant fruit, green tea, grape seed, leucocyanidins of grape seed, pine bark, apple, pomegranate, bilberry, red vine, citrus pericarp, bitter orange, cocoa, aronia, raspberry leaf, hibiscus, olive leaf, olive fruit and a mix of olive fruit and leaf) was assessed on porcine coronary artery rings. Among all extracts, the most important endothelium-dependent vasorelaxation were obtained with grape seed (EC50=0.87 µg/ml and 2.0 µg/ml), leucocyanidins of grape seed (EC50=1.6 µg/ml), pine bark (EC50=2.2 µg/ml and 3.1 µg/ml), apple (EC50=2.2 µg/ml), cocoa (EC50=3.6 µg/ml), black currant (EC50=6.6 µg/ ml), pomegranate (EC50=6.6 µg/ml) and aronia EC50=12.7 µg/ml). The efficiency of all extracts (EC50) were significantly correlated with their content in total polyphenols (r=0.70; p=0.0002; n=23), in flavanols (r=0.65; p=0.031; n=11) and in flavonols (r=0.57; p=0.016; n=17). Our results suggest that some polyphenol-rich extracts could be potentially interesting to maintain a good cardiovascular health.