Abstract
Introduction High soluble Flt1 (sFlt1) is pivotal in the development of ‘preeclampsia phenotype’ of hypertension and proteinuria. Disruption of endogenous protective pathways and increased oxidative stress are hallmarks.of preeclampsia. Yet the underlying molecular mechanisms remains unclear. During high oxidative stress, thiols on key proteins are reversibly modified by S-glutathionylation, which can be enzymatically removed by Glutaredoxin-1(Glrx). We investigated the role of Glrx in preeclampsia. Results Glrx mRNA and protein expression were increased while -SSG adducts were lower in placenta from early onset preeclamptic ( Summary These data support the proposed hypothesis that Glrx regulates sFlt1 expression to promote the ‘PE phenotype’.
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