Abstract
AbstractCopper(II)–amino acid (AA) complexes that contain 2,2′‐bipyridine (bpy) as supporting ligand were investigated. X‐ray structural analysis of three new bpy‐based complexes revealed a bidentate coordination of the AAs on the copper(II) centers similar to that proposed for the substrate on the iron(II) center of the 1‐aminocyclopropane‐1‐carboxylic acid oxidase (ACCO). Similar complexes with two aminophosphonic acids (APAs), 1‐aminocyclopropane‐1‐phosphonic acid (ACP) and (1‐amino‐1‐methyl)ethylphosphonic acid (AMEP), were also investigated, and the latter complex was structurally characterized. This structure reveals the bidentate coordination of α‐aminophosphonate on the copper(II) ion. The oxidation of the bound amino acids (AAs) and aminophosphonates (APAs), which model the reaction catalyzed by ACCO, was investigated. The complexes react with H2O2 and give oxidation products that were identified by gas chromatography. Reduction of CuII to CuI was detected by UV/Vis spectroscopy upon reaction with H2O2 or ascorbate. This reduction is proposed to be the initial step for the peroxide/copper activation prior to the oxidation of the AA and APA ligands by means of a radical mechanism.
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