Abstract
It has been established that antenatal pathology causes changes in the oxidant/antioxidant balance indices of cows within the range from 24.3% to 41.5%, and in sheep - 17.2-26.2%. In particular, in cows the content of serum catalase decreased by 29.9% and that of superoxide dismutase - by 29.1%, in erythrocytes, catalase - by 35.7%, and reduced glutathione - by 28.0%, and by hemoglobin by 24.3%, the number of red blood cells - by 28.7% and the concentration of 2,3-diphosphoglycerate - by 41.5%. At the same time, the content of malondialdehyde in serum and erythrocytes, on the contrary, increased by 32.4% and 32.5%, respectively, and there was a change in oxidant/antioxidant balance from 1 : 1 to 1 : 3 conventional units. In sheep, the content of serum catalase decreased by 17.2% and that of superoxide dismutase - by 21.6%, in erythrocytes catalase - by 23.9% and in reduced glutathione - by 21.1%, hemoglobin content decreased by 26.2%, the number of erythrocytes - by 24,1% and the concentration of 2,3-diphosphoglycerate - by 21.2%. While the content of malondialdehyde in blood serum and in erythrocytes, on the contrary, increased by 23.7% and 22.3%, respectively, and the change in oxidant/antioxidant balance occurred from 2:1 to 1:3 conventional units.
Highlights
The study is a fragment of the research projects in Ukraine: “Development and introduction of innovative methods and solutions using information technology devices in veterinary reproduction” and “Clinical correction of anthropogenic origin ecological destructions in domestic animals of Prydniprovsk industrial region”
Due to the urgency and general needs of the veterinary medicine practice, antenatal pathology should be considered in a delimited, double variant, taking into account the parallel existence of the problems: 1) development and implementation of a system of diagnostic, treatment and preventive measures that ensure the normal course of pregnancy; 2) development and implementation of a system of diagnostic, treatment and preventive measures that provide optimal conditions for development and health of the embryo / fetus (Fotina et al, 2018, Zazharskyi et al, 2019b, Erişir et al, 2009, Gür et al, 2011)
One of the directions that will allow a more complete study of physiological and pathological aspects of antenatal development is the study of the oxidant/antioxidant balance, since the detection of damage caused by free radicals and protection of the body against it become more and more important in clinical medicine as an auxiliary tool for the metabolic status assessment
Summary
The study is a fragment of the research projects in Ukraine: “Development and introduction of innovative methods and solutions using information technology devices in veterinary reproduction” and “Clinical correction of anthropogenic origin ecological destructions in domestic animals of Prydniprovsk industrial region”. The content of catalase was reduced after the 1 st month of pregnancy, and Oxidant/Antioxidant balance in cows and sheep the lowest - in the 2nd and the 3rd months Such changes in the studied indices may indicate a predisposition to the oxidative stress in the 2nd and the 3rd months of pregnancy in sheep. Some aspects, including the oxidant/antioxidant balance in the intrauterine development disorder, remain slightly clarified in general, remain poorly highlighted at all. In this regard, the purpose of the research was to determine the oxidant/antioxidant balance in cows and sheep as a marker in software for diagnosis, therapy and prevention of antenatal pathology
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