Abstract
BackgroundTo evaluate the ototoxicity of acetic acid solutions.MethodsCompound action potentials (CAPs) of the eighth nerve were measured in guinea pigs before and after the application of acetic acid in the middle ear cavity. The pH values of the acetic acid solutions were pH 3.0, 4.0, and 5.0, and the application times were 30 min, 24 h, and 1 week.ResultsAcetic acid solution (pH 3.0, N = 3) for 30 min caused no significant elevation in CAP threshold at 4 kHz, but a significant elevation in the threshold was noted for 8 kHz and clicks. Acetic acid solutions (pH 4.0 N = 6, 5.0 N = 5) for 30 min caused no significant elevation in CAP. Acetic acid solution (pH 4.0) for 24 h (N = 5) caused significant elevations of the CAP threshold for 8 kHz, 4 kHz, and for clicks. Acetic acid (pH 5.0) for 24 h (N = 3) caused a significant elevation of the CAP threshold for 4 kHz, but not for 8 kHz or clicks. Acetic acid (pH 5.0) for 1 week (N = 3) caused a small but significant elevation CAP the threshold for 8 kHz and 4 kHz tone bursts, but no significant change was noted for clicks.ConclusionsWe found a significant toxic effect of acetic acid in guinea pigs on eighth-nerve compound action potentials when the pH was 5.0 or lower. Clearly, the stronger the acidity, and longer the exposure time, the more the CAP threshold was elevated.
Highlights
To evaluate the ototoxicity of acetic acid solutions
No significant elevation in Compound action potentials (CAPs) threshold was noted at 30 min
No change in CAP threshold was noted at 30 min
Summary
To evaluate the ototoxicity of acetic acid solutions. The purpose of this study is to elucidate the effect of various acidity of acetic acid on the guinea pig cochlea. Ototoxicity of Burow’s solution on the guinea pig cochlea was reported by us (1). Main ingredient of Burow’s solution is 13 % aluminum acetate. Original Burow’s solution has a pH 3.5 which caused a significant reduction of compound action potential (CAP) when applied in the middle ear cavity for 30 min, while a two fold diluted Burow’s solution (pH 4.4) caused no reduction in CAP threshold. No study has been performed to determine ototoxicity of acetic acid with various pH. Animals To evaluate the ototoxicity of various acidity (pH) of acetic acid, alubino Hartley guinea pigs of both genders (in total N = 30) were used. Animals selected had an average body weight between 300 and 400 g and had a positive Prayer reflex
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