Osteogenic Effectiveness Of 3d Printed Polycaprolactone Scaffold Implanted with Metallic Bone Regenerative Compounds - A Systematic Review

Abstract

The design and fabrication of synthetic scaffolds to stimulate bone repair have been extensively researched and have experienced a remarkable increase in interest over the last decade. The aim of the current review is to systematically analyse the scientific evidence on osteogenic effectiveness of 3D printed polycaprolactone scaffold implanted with metallic bone regenerative compounds. To achieve the goal, this study conducted a systematic review of the global research published on 3D printed polycaprolactone scaffolds and a total of 338 were analysed by evaluating title, author and year, study design, sample size, groups, types of statistical methods used, outcome measures and inference. After excluding articles based on inclusion and exclusion criteria, a total of 5 articles were reviewed. The future trend is proposed by the systematic review and is discussed in the directions of biocompatibility, cell adhesion and proliferation, mechanical properties, gene expression, osteoblastic bone formation and graft degeneration. This study contributes by providing knowledge for practitioners and researchers to understand the state of the art of scaffold manufacturing with polycaprolactone with regenerative compounds and expose its research needs, which can serve both academia and industry.