Abstract
2006; 11: 89-96, ISSN 1342-0984In the present study, rat bone marrow (RBM) cells were cultured on dental implants. Afterprimary culture, RBM cells were cultured on dental implants for 2 weeks with and withoutosteogenic factors. DNA, alkaline phosphatase activity, osteocalcin and osteopontin weremeasured. Biochemical analyses revealed that, on the dental implants, RBM cell differentiationinto osteoblasts was induced by osteogenic factors. Dental implants with and without culturedRBM cells were implanted in the subcutaneous tissue or on the femur in syngeneic rats.Osteogenesis in the subcutaneous tissue and more extensive and faster bone formation aroundthe femur were observed for the implants combined with cells cultured with osteogenic factors.These results demonstrated that dental implants combined with osteoblasts differentiated fromRBM cells with osteogenic factors were effective for osseointegration and bone formation.
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