Organic Synthesis in Flow

Abstract

The use of miniaturized reactors operating in continuous flow allows synthetic chemists to carry out unique transformations that cannot be achieved using traditional batch reactors. Due to their specific features, these flow reactors provide a firm grip on mass and heat transfer, as well on reaction time. It is therefore possible to trap short-living intermediates and to handle hazardous compounds in a much safer way than conventional batch reactors. This chapter discusses the basic principles of flow chemistry (advantages and limitations) followed by selected examples where their properties really bring a significant input.