Abstract
Oral Infection - Parkinson's Disease, Concepts of Neuroinflammation. Could there be a New Investigation Model?
Highlights
Besides inducing systemic inflammation, increasing evidence implies that periodontitis provokes chronic inflammation associated with activation of microglia, the immune cells in the brain, which is referred to as neuroinflammation
The present review presents an overview of the evidence linking periodontitis with Parkinson’s disease and calls for increased cooperation between dentists and medical doctors to provide optimal screening, treatment, and prevention of both Parkinson’s disease and its comorbidities [2]
All the inflammatory mediators and ROS species released by activated microglial cells increases the neurotoxicity and contributes to neurodegeneration of dopaminergic neurons of SN eventually causing Parkinson’s disease
Summary
Periodontitis is a chronic, oral poly microbial infection affecting nearly 60% of the population worldwide and is the most prevalent oral inflammatory disease in adults. Periodontitis is an oral localized inflammatory disease, and elicits low-grade systemic inflammation via both the release of pro-inflammatory cytokines and the invasion of periodontopathic bacteria. Besides inducing systemic inflammation, increasing evidence implies that periodontitis provokes chronic inflammation associated with activation of microglia, the immune cells in the brain, which is referred to as neuroinflammation. Based on the aforementioned findings, chronic inflammation can be regarded as a common denominator of periodontitis and neuropsychiatric disorders.
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