Abstract
Background/Aim: The present analysis focuses on examining a case series of eight patients diagnosed with a granular cell tumor located in the oral cavity. Case series: The patients’ clinical states were thoroughly studied, along with the histopathological and immunohistochemical examinations findings. Their surgical treatment and postoperative course are also within the scope of this analysis. Numerous histogenesis theories and the appropriate tumor treatment are mentioned within the article being always in accordance with the relative literature. Conclusions: Oral granular cell tumor is a benign oral disease of possible neural origin commonly located on the tongue. Surgical excision is the treatment of choice. In any case, histological and immunohistochemical examination confirm both the clinical diagnosis and the differential diagnosis between oral squamous cell carcinoma.
Highlights
The granular cell tumor (GCT) appears to be a benign neoplasm, probably of neural origin, which is usually located in the head and neck area (45% to 65% of the cases)[1]
That lesion was first described by Arbikossoff in 1926, stating that the granular cells of the tumor derive from the skeletal muscles and was termed myovlastoma[3,5]
In support of the last theory, the GCT is positive to the S-100 protein during the immunohistochemical examination, just as in our case[7,8]
Summary
The granular cell tumor (GCT) appears to be a benign neoplasm, probably of neural origin, which is usually located in the head and neck area (45% to 65% of the cases)[1]. That lesion was first described by Arbikossoff in 1926, stating that the granular cells of the tumor derive from the skeletal muscles and was termed myovlastoma[3,5]. Other theories of histogenesis claim that GCT derives from neurons, fibroblasts, mast cells and myoepithelial cells[6]. According to the prevailing theory, the oral GCT derives from cells of the neural tissue, and from the Schwann cells[6,7,8]. In support of the last theory, the GCT is positive to the S-100 protein during the immunohistochemical examination, just as in our case[7,8]. Middle third of 1 cm diameter, 55 Male the right side of perceptible 10 the tongue years
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