Abstract
Oral disintegrating films (ODF) are recently being explored overcome the problem faced by pediatric and geriatric populations of swallowing the tablets. Oral disintegrating films disintegrate in the mouth cavity infraction of time and then they are to be swallowed. Remarkably, after getting swallowed by the patient, they should dissolve and release the drug in the GI track. The ODF is simply placed on the tongue or any oral mucosal tissue which makes the film wet, rapidly disintegrate and dissolve to immediate release of medication for oral absorption. It is the advance form of solid dosage form due to their flexibility and enhances the release rate of API within the seconds. There are various polymers used in ODF as an individual or in combination to obtain desirable properties such as Mechanical strength, Drug loading capacity, Drug release and Disintegration time. Depending on the content and type of polymer selected for the preparation of optimized formulation of ODF, which has to be disintegrate within a seconds after make in contact with mouth. ODFs are characterized for the quality parameters like Physical strength, Appearance, Drug release profile, Residual water content, Dose uniformity, Organoleptic characteristics and Stability. Thus, the oral disintegrating films can be a novel promising approach for patient compliance with faster onset of action.
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