Abstract
The mucilage from Brasenia schreberi (BS) exhibits various biological activities, including antialgal, antibacterial, soluble-fiber properties, and excellent lubricating behavior. Thus, the extraction and wide use of mucilage in the food industry are crucial. In this study, the high-speed shear-assisted extraction of mucilage from BS was optimized by using response surface methodology (RSM). The optimal extraction conditions were as follows: Extraction temperature of 82 °C, extraction time of 113 min, liquid–solid ratio of 47 mL/g, and shear speed of 10,000 rpm. Under these conditions, the actual yield of BS mucilage was 71.67%, which highly matched the yield (73.44%) predicted by the regression model. Then, the BS mucilage extract was powdered to prepare the capsule, and the excipients of the capsule were screened using a single-factor test to improve the disintegration property and flowability. The final capsule formulation, which consisted of: 39% BS mucilage powder (60 meshes); 50% microcrystalline cellulose (60 meshes) as the filler; both 10% sodium starch glycolate and PVPP XL-10 (3:1, 60 meshes) as the disintegrant; both 1% colloidal silicon dioxide and sodium stearyl fumarate (1:1, 100 meshes) as the glidant by weight; were used for preparing the weights of a 320 mg/grain of capsule with 154.7 ± 0.95 mg/g polysaccharide content. Overall, the optimized extraction process had a high extraction rate for BS mucilage and the capsule formulation was designed reasonably.
Highlights
IntroductionThe perennial water plant Brasenia schreberi (BS) is an invasive aquatic weed found in the USA but is considered a kind of medicinal and edible plant in Asia, where it is cultivated and traded [1]
The perennial water plant Brasenia schreberi (BS) is an invasive aquatic weed found in the USA but is considered a kind of medicinal and edible plant in Asia, where it is cultivated and traded [1].In China, BS has been consumed as a functional food for millennia owing to its high nutritional value and biological activities, including antibacterial, antioxidant, anti-inflammatory, hypolipidemic, and cholesterol-lowering effects [2,3,4]
Response surface methodology (RSM) is a statistical technique usually used for quantitative data from suitable experimental designs and for determining and solving multivariate equations
Summary
The perennial water plant Brasenia schreberi (BS) is an invasive aquatic weed found in the USA but is considered a kind of medicinal and edible plant in Asia, where it is cultivated and traded [1]. In China, BS has been consumed as a functional food for millennia owing to its high nutritional value and biological activities, including antibacterial, antioxidant, anti-inflammatory, hypolipidemic, and cholesterol-lowering effects [2,3,4]. Over the last few years, the absorption of therapeutic capsules has received great interest because of their high bioavailability, fast absorption and disintegration, good stability, simpler production process compared with other administration routes, and ability to offset the bitterness and odor of materials [15,16]. Mucilage was extracted from BS through a high-speed shear-assisted method because of the abundant human health-promoting effects of mucilage and distinguished advantages of capsule preparation. The excipient formulation of the capsule was screened, and the capsule, along with polysaccharide, weight, and water content, was evaluated, thereby providing basic pharmaceutical research for the preparation of capsules by BS mucilage
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