Optimizing extractionprocess of Chonglian oral solution by orthogonal test

Abstract

：Objective To optimizeChonglian oral solution extracting craft. Methods With the obtaining rate of extract andthe total content of the Pariphyllin Ⅰand Phillyrinpresented in the extract as the indexes for the water extraction process,and with thetotal content of the Pariphyllin Ⅰ and Phillyrin presented inthe extract as the indexes for the alcohol deposition process,orthogonal design was usedto optimize the conditions for the extraction process respectively. Results The optimalconditions for the water extraction of Chonglian oral solution was as following:to addwater 10 times,decocting 3 times,1 hour each time.The optimal conditions for the alcoholdeposition of Chonglian oral solution was as following:concentrated for the relativedensity to 1.10(80C hot test),cold,add ethanol to the solution for the ethanol content ofthe solution reached 80%,static settlement for 24 hours. Conclusion The extracting methodis reasonable,stable,and suitable to industrialized producting.