Abstract
The results of Fourier transform infrared, differential scanning calorimetry and powder X-ray diffraction revealed that tetrandrine would be either molecularly dispersed in the polymer or distributed in an amorphous form
Highlights
Tetrandrine, with the molecular formula of C33H42N2O6 (Fig. 1), a bisbenzylisoquinoline alkaloid isolated from the root of Fangji
The objective of this study was to develop uniform-sized tetrandrine-loaded polylactide (PLA) microspheres prepared by the Shirasu Porous Glass (SPG) membrane emulsification technique with the emulsion-solvent evaporation method for pulmonary inhalation
Influence of transmembrane pressure on the characteristics of PLA particles As transmembrane pressure increased from 0.02 MPa to 0.14 MPa, the average size of the PLA microspheres increased from
Summary
Tetrandrine, with the molecular formula of C33H42N2O6 (Fig. 1), a bisbenzylisoquinoline alkaloid isolated from the root of Fangji The microsphere size can be controlled within 2-10 μm and optimized to within 2-5 μm; this size is most effective for inhalation applications, as particles over 5 μm are limited to the upper airways by inertial impaction [15,16] This novel method is advantageous for several important reasons: (1) controlled droplet size and narrow droplet size distribution are possible under the proper conditions [17,18], (2) the practical and theoretical evaluation of properties, such as the drug release rate, would become simple and precise with uniformsized microcapsules, and the burst effect could be avoided [1920], and (3) owing to its ease of operation, simple equipment, mildness without violent stirring and low energy consumption during the process, many drugs sensitive to light, heat, oxygen or collision have been applied in this method [21,22,23]. The in vitro experiment revealed the drug release behavior of the tetrandrine-loaded PLA microspheres
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
