Abstract
Abstract The aim of the present study was to give insight into the mechanisms of action of ethanol on the function of retinal ON and OFF channels. In order to fulfill this aim the effects of ethanol on the electroretinographic (ERG) ON
Highlights
Acute consumption of ethyl alcohol affects a variety of visual functions, but the site where ethanol exerts its action is largely unknown
Some of ethanol effects may originate in the retina, while others may have their origin in the higher brain visual centers
It has been shown that the blockade of proximal retinal activity with NMDA did not prevent the enhancing effect of picrotoxin on the b-wave amplitude. These results suggest that the endogenous GABA released by horizontal cells in the distal retina has an inhibitory effect on the activity of ON bipolar cells, whose activity is responsible for the b-wave generation
Summary
Acute consumption of ethyl alcohol (ethanol) affects a variety of visual functions, but the site where ethanol exerts its action is largely unknown. Alcohol-induced decrease in lateral inhibition under different conditions of light adaptation has been observed in humans with psychophysical performance in assessments of visual function [3,4]. It appears that some ethanol actions on visual functions are due to decreased lateral inhibition. This action could occur at the level of ganglion cells in the proximal retina, and at the level of bipolar cells in the distal retina
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