One-pot synthesis of secondary and tertiary naphthylpropylamines by rhodium(I)-catalysed carbonylative hydroaminomethylation

Abstract

Secondary and tertiary naphthylpropylamines are prepared in high yields by the reaction of 2-vinylnaphthalene, primary or secondary amines, carbon monoxide and hydrogen in presence of [Rh(cod)Cl] 2 as catalyst via a one-pot hydroformylation - amine condensation - reduction sequence.