One-pot synthesis of 1,4-diamines from allyl halides and amines via a rhodium-catalysed multistep reaction sequence under hydroformylation conditions

Abstract

1,4-Diamines 8 are prepared with good yields and selectivities by the reaction of methallyl chloride ( 6), secondary amines 7, carbon monoxide and hydrogen in presence of [Rh(cod)Cl] 2 as catalyst via a one-pot nucleophilic substitution - hydroformylation - amine condensation - reduction sequence.